作者
Jiangtao Gao, Mohamed M Radwan, Francisco León, Olivia Reed Dale, Afeef S Husni, Yunshan Wu, Shari Lupien, Xiaoning Wang, Susan P Manly, Robert A Hill, Frank M Dugan, Horace G Cutler, Stephen J Cutler
发表日期
2013/5/24
期刊
Journal of natural products
卷号
76
期号
5
页码范围
824-828
出版商
American Chemical Society and American Society of Pharmacognosy
简介
Bioassay-guided fractionation of a fungus Neocosmospora sp. (UM-031509) resulted in the isolation of three new resorcylic acid lactones, neocosmosin A (2), neocosmosin B (3), and neocosmosin C (4). Three known resorcylic acid lactones, monocillin IV (1), monocillin II (5), and radicicol (6), were also isolated and identified. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analysis, mass spectrometric (ESIMS) data, and X-ray crystallography. Compounds 4–6 show good binding affinity for the human opioid receptors. These findings have important implications for evaluating the potential psychoactive effects with this class of compounds.
学术搜索中的文章
J Gao, MM Radwan, F León, OR Dale, AS Husni, Y Wu… - Journal of natural products, 2013