作者
Waldemar Siemens, Carola Xander, Joerg J Meerpohl, Gerd Antes, Gerhild Becker
发表日期
2014/12
来源
Deutsches Ärzteblatt International
卷号
111
期号
50
页码范围
863
出版商
Deutscher Arzte-Verlag GmbH
简介
Background
Pruritus is a rare but troublesome symptom in palliative-care patients with a variety of underlying diseases. The pharmacotherapy of pruritus is often off-label, and an evidence-based evaluation is needed.
Method
A Cochrane Review published in 2013 was updated with a systematic literature search up to January 2014. Randomized and controlled trials (RCTs) with adult palliative-care patients were included.
Results
In the 43 RCTs that were analyzed, three of which were more recent than the Cochrane Review, 8 clinically relevant active substances were investigated in a total of 19 RCTs. Effective drugs for pruritus in palliative-care patients included paroxetine for pruritus of diverse origins (1 RCT; strong effect) and indomethacin for HIV-induced prutitus (1 RCT; median effect= moderate reduction). Effective drugs for pruritus in uremia were gabapentin (2 RCTs; strong effect), nalfurafin (3 RCTs; moderate …
学术搜索中的文章
W Siemens, C Xander, JJ Meerpohl, G Antes, G Becker - Deutsches Ärzteblatt International, 2014