作者
Merryn Voysey, Sue Ann Costa Clemens, Shabir A Madhi, Lily Y Weckx, Pedro M Folegatti, Parvinder K Aley, Brian Angus, Vicky L Baillie, Shaun L Barnabas, Qasim E Bhorat, Sagida Bibi, Carmen Briner, Paola Cicconi, Elizabeth A Clutterbuck, Andrea M Collins, Clare L Cutland, Thomas C Darton, Keertan Dheda, Christina Dold, Christopher JA Duncan, Katherine RW Emary, Katie J Ewer, Amy Flaxman, Lee Fairlie, Saul N Faust, Shuo Feng, Daniela M Ferreira, Adam Finn, Eva Galiza, Anna L Goodman, Catherine M Green, Christopher A Green, Melanie Greenland, Catherine Hill, Helen C Hill, Ian Hirsch, Alane Izu, Daniel Jenkin, Carina CD Joe, Simon Kerridge, Anthonet Koen, Gaurav Kwatra, Rajeka Lazarus, Vincenzo Libri, Patrick J Lillie, Natalie G Marchevsky, Richard P Marshall, Ana VA Mendes, Eveline P Milan, Angela M Minassian, Alastair McGregor, Yama F Mujadidi, Anusha Nana, Sherman D Padayachee, Daniel J Phillips, Ana Pittella, Emma Plested, Katrina M Pollock, Maheshi N Ramasamy, Adam J Ritchie, Hannah Robinson, Alexandre V Schwarzbold, Andrew Smith, Rinn Song, Matthew D Snape, Eduardo Sprinz, Rebecca K Sutherland, Emma C Thomson, M Estée Török, Mark Toshner, David PJ Turner, Johan Vekemans, Tonya L Villafana, Thomas White, Christopher J Williams, Alexander D Douglas, Adrian VS Hill, Teresa Lambe, Sarah C Gilbert, Andrew J Pollard, Marites Aban, Kushala WM Abeyskera, Jeremy Aboagye, Matthew Adam, Kirsty Adams, James P Adamson, Gbadebo Adewatan, Syed Adlou, Khatija Ahmed, Yasmeen Akhalwaya, Saajida Akhalwaya, Andrew Alcock, Aabidah Ali, Elizabeth R Allen, Lauren Allen, Felipe B Alvernaz, Fabio Santos Amorim, Claudia Sala Andrade, Foteini Andritsou, Rachel Anslow, Edward H Arbe-Barnes, Mark P Ariaans, Beatriz Arns, Laiana Arruda, Luiza Assad, Paula De Almeida Azi, Lorena De Almeida Azi, Gavin Babbage, Catherine Bailey, Kenneth F Baker, Megan Baker, Natalie Baker, Philip Baker, Ioana Baleanu, Danieli Bandeira, Anna Bara, Marcella AS Barbosa, Debbie Barker, Gavin D Barlow, Eleanor Barnes, Andrew S Barr, Jordan R Barrett, Jessica Barrett, Kelly Barrett, Louise Bates, Alexander Batten, Kirsten Beadon, Emily Beales, Rebecca Beckley, Sandra Belij-Rammerstorfer, Jonathan Bell, Duncan Bellamy, Sue Belton, Adam Berg, Laura Bermejo, Eleanor Berrie, Lisa Berry, Daniella Berzenyi, Amy Beveridge, Kevin R Bewley, Inderjeet Bharaj, Sutika Bhikha, Asad E Bhorat, Zaheda E Bhorat, Else Margreet Bijker, Sarah Birch, Gurpreet Birch, Kathryn Birchall, Adam Bird, Olivia Bird
发表日期
2021/3/6
期刊
The Lancet
卷号
397
期号
10277
页码范围
881-891
出版商
Elsevier
简介
Background
The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4–12 weeks. The planned roll-out in the UK will involve vaccinating people in high-risk categories with their first dose immediately, and delivering the second dose 12 weeks later. Here, we provide both a further prespecified pooled analysis of trials of ChAdOx1 nCoV-19 and exploratory analyses of the impact on immunogenicity and efficacy of extending the interval between priming and booster doses. In addition, we show the immunogenicity and protection afforded by the first dose, before a booster dose has been offered.
Methods
We present data from three single-blind randomised controlled trials—one phase 1/2 study in the UK (COV001), one phase 2/3 study in the UK …
学术搜索中的文章
M Voysey, SAC Clemens, SA Madhi, LY Weckx… - The Lancet, 2021