作者
Joseph N Jarvis, Tihana Bicanic, Angela Loyse, Daniel Namarika, Arthur Jackson, Jesse C Nussbaum, Nicky Longley, Conrad Muzoora, Jacob Phulusa, Kabanda Taseera, Creto Kanyembe, Douglas Wilson, Mina C Hosseinipour, Annemarie E Brouwer, Direk Limmathurotsakul, Nicholas White, Charles Van Der Horst, Robin Wood, Graeme Meintjes, John Bradley, Shabbar Jaffar, Thomas Harrison
发表日期
2014/3/1
期刊
Clinical infectious diseases
卷号
58
期号
5
页码范围
736-745
出版商
Oxford University Press
简介
Background. Cryptococcal meningitis (CM) is a leading cause of death in individuals infected with human immunodeficiency virus (HIV). Identifying factors associated with mortality informs strategies to improve outcomes.
Methods. Five hundred one patients with HIV-associated CM were followed prospectively for 10 weeks during trials in Thailand, Uganda, Malawi, and South Africa. South African patients (n = 266) were followed for 1 year. Similar inclusion/exclusion criteria were applied at all sites. Logistic regression identified baseline variables independently associated with mortality.
Results. Mortality was 17% at 2 weeks and 34% at 10 weeks. Altered mental status (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.7–5.9), high cerebrospinal fluid (CSF) fungal burden (OR, 1.4 per log10 colony-forming units/mL increase; 95% CI, 1.0–1 …
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