作者
Rebecca M Dyson, Hannah K Palliser, Nicole Wilding, Megan A Kelly, Grazyna Chwatko, Rafal Glowacki, Mary J Berry, Xin Ni, Ian MR Wright
发表日期
2019/2
期刊
Microcirculation
卷号
26
期号
2
页码范围
e12507
简介
Objective
H2S may explain the dysregulation of microvascular tone associated with poor outcome following preterm birth. In adult vasculature, H2S is predominantly produced by CSE. We hypothesized that vascular CSE activity contributes to microvascular tone regulation during circulatory transition.
Methods
Preterm (GA62) and full‐term (GA69) guinea pig fetuses and neonates were studied. Microvascular blood flow was assessed by laser Doppler flowmetry. Thiosulfate, primary urinary metabolite of H2S, was determined by high‐performance liquid chromatography. Real‐time H2S production was assessed using a microrespiration system in fetal and postnatal (10, 24 hours) skin and heart samples. CSE contribution was investigated by inhibition via propargylglycine.
Results
In preterm animals, postnatal H2S production capacity in peripheral vasculature increased significantly and was significantly reduced …
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RM Dyson, HK Palliser, N Wilding, MA Kelly… - Microcirculation, 2019