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Previous studies have reported associations between short-term exposure to fine particulate matter (PM2.5) and acute cardiac events. However, the effect of long-term exposure to PM2.5 on the risk of sudden cardiac death (SCD) is unknown. We prospectively examined associations between medium- and long-term exposures to PM2.5 and incidence of SCD in the Nurses’ Health Study (NHS) cohort, a nationwide prospective cohort of female nurses in the US. Women in NHS (N=117,358) were followed via biennial questionnaires. Spatiotemportal prediction models were used to estimate monthly time-varying, residential exposure to PM2.5. To enable examination of different time windows of exposure simultaneously, given the high correlation between time windows, we calculated cumulative average PM2.5, the difference between the cumulative average and 12-month moving …