作者
Sadra Samavarchi Tehrani, Fataneh Esmaeili, Moein Shirzad, Golnaz Goodarzi, Tooba Yousefi, Mahmood Maniati, Mortaza Taheri‐Anganeh, Amir Anushiravani
发表日期
2023/3/14
来源
Medical Oncology
卷号
40
期号
4
页码范围
116
出版商
Springer US
简介
Nowadays, drug resistance (DR) in gastrointestinal (GI) cancers, as the main reason for cancer-related mortality worldwide, has become a serious problem in the management of patients. Several mechanisms have been proposed for resistance to anticancer drugs, including altered transport and metabolism of drugs, mutation of drug targets, altered DNA repair system, inhibited apoptosis and autophagy, cancer stem cells, tumor heterogeneity, and epithelial-mesenchymal transition. Compelling evidence has revealed that genetic and epigenetic factors are strongly linked to DR. Non-coding RNA (ncRNA) interferences are the most crucial epigenetic alterations explored so far, and among these ncRNAs, circular RNAs (circRNAs) are the most emerging members known to have unique properties. Due to the absence of 5’ and 3’ ends in these novel RNAs, the two ends are covalently bonded together and are …
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S Samavarchi Tehrani, F Esmaeili, M Shirzad… - Medical Oncology, 2023