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To assess the fetal loss rate following amniocentesis and chorionic villus sampling (CVS).

This was a national registry‐based cohort study, including all singleton pregnant women who had an amniocentesis (n = 32 852) or CVS (n = 31 355) in Denmark between 1996 and 2006. Personal registration numbers of women having had an amniocentesis or a CVS were retrieved from the Danish Central Cytogenetic Registry, and cross‐linked with the National Registry of Patients to determine the outcome of each pregnancy. Postprocedural fetal loss rate was defined as miscarriage or intrauterine demise before 24 weeks of gestation.

The miscarriage rates were 1.4% (95% CI, 1.3–1.5) after amniocentesis and 1.9% (95% CI, 1.7–2.0) after CVS. The postprocedural loss rate for both procedures did not change during the 11‐year study period, and was not correlated with maternal age. The …