作者
Anna L Walsh, Alexandra V Tuzova, Eva M Bolton, Thomas H Lynch, Antoinette S Perry
发表日期
2014/8/1
来源
Trends in molecular medicine
卷号
20
期号
8
页码范围
428-436
出版商
Elsevier
简介
Long noncoding RNAs (lncRNAs) are rapidly becoming essential pieces in the cancer puzzle. Our understanding of their functional capabilities is in its infancy. One certain fact, however, is that their molecular interactions extend beyond chromatin complexes into diverse biological processes. In prostate cancer, aberrant expression of lncRNAs is associated with disease progression. Overexpression of oncogenic lncRNAs promotes tumor-cell proliferation and metastasis through chromatin looping and distal engagement with the androgen receptor, antisense gene regulation, alternative splicing, and impeding DNA repair. Several lncRNAs, such as prostate cancer antigen 3 (PCA3), prostate cancer gene expression marker 1 (PCGEM1), and prostate cancer associated ncRNA transcript 1 (PCAT1), are highly prostate-specific, posing as attractive biomarkers. Herein we review the mechanisms of action of lncRNAs in …
学术搜索中的文章
AL Walsh, AV Tuzova, EM Bolton, TH Lynch, AS Perry - Trends in molecular medicine, 2014