作者
Antoinette S Perry, Gillian O'Hurley, Omer A Raheem, Kevin Brennan, Simon Wong, Anthony O'Grady, Anne‐Marie Kennedy, Laure Marignol, Therese M Murphy, Linda Sullivan, Ciara Barrett, Barbara Loftus, John Thornhill, Stephen M Hewitt, Mark Lawler, Elaine Kay, Thomas Lynch, Donal Hollywood
发表日期
2013/4/15
期刊
International journal of cancer
卷号
132
期号
8
页码范围
1771-1780
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Aberrant activation of Wnts is common in human cancers, including prostate. Hypermethylation associated transcriptional silencing of Wnt antagonist genes SFRPs (Secreted Frizzled‐Related Proteins) is a frequent oncogenic event. The significance of this is not known in prostate cancer. The objectives of our study were to (i) profile Wnt signaling related gene expression and (ii) investigate methylation of Wnt antagonist genes in prostate cancer. Using TaqMan Low Density Arrays, we identified 15 Wnt signaling related genes with significantly altered expression in prostate cancer; the majority of which were upregulated in tumors. Notably, histologically benign tissue from men with prostate cancer appeared more similar to tumor (r = 0.76) than to benign prostatic hyperplasia (BPH; r = 0.57, p < 0.001). Overall, the expression profile was highly similar between tumors of high (≥ 7) and low (≤ 6) Gleason scores …
学术搜索中的文章
AS Perry, G O'Hurley, OA Raheem, K Brennan, S Wong… - International journal of cancer, 2013
