作者
Mikkel Højlund, Larus S Gudmundsson, Jacob H Andersen, Leena K Saastamoinen, Helga Zoega, Svetlana O Skurtveit, Jonas W Wastesson, Jesper Hallas, Anton Pottegård
发表日期
2023/1
期刊
Basic & Clinical Pharmacology & Toxicology
卷号
132
期号
1
页码范围
60-70
简介
Use of benzodiazepines (BZ) and related drugs is subject to considerable debate due to problems with dependency and adverse events. We aimed to describe and compare their use across the Nordic countries. Data on the use of clonazepam, BZ‐sedatives, BZ‐hypnotics, and benzodiazepine‐related drugs (BZRD) in adults (≥20 years) were obtained from nationwide registers in Denmark, Finland, Iceland, Norway, and Sweden, 2000–2020. Main measures were therapeutic intensity (TI:DDD/1000 inhabitants [inhab.]/day) and annual prevalence (users/1000 inhab./year). Overall, TI of BZ and related drugs decreased in all Nordic countries from 2004 to 2020. However, there were considerable differences between countries in TI. In 2020, the TI of BZ and related drugs ranged from 17 DDD/1000 inhab./day in Denmark to 93 DDD/1000 inhab./day in Iceland. BZRD accounted for 55–78% of BZ use in 2020, followed …
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M Højlund, LS Gudmundsson, JH Andersen… - Basic & Clinical Pharmacology & Toxicology, 2023