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Since ancient times, Psoralea corylifolia (Leguminosae), also known as babchi or babachi, has been used in various traditional systems of various ailments. Psoralea corylifolia is found throughout Asia, including Pakistan and many other countries. Its medicinal use is documented in of British, American, and Chinese pharmacopoeias, as well as various traditional systems of medicine such as Unani, Siddha and Ayurveda. The objective of this chapter is to present a thorough overview of Psoralea corylifolia’s phytochemical and pharmacological properties. It has been used in traditional medicine to treat a variety of ailments, including, cardiovascular issues, leukoderma skin conditions, osteoporosis, nephritis, and cancer, as well as poisoning, vitiligo, deafness, caries and filarial. This plant’s leaves, stem, and seeds contained a variety of biologically active compounds, including quinines, flavonoids, phenols …