作者
Tooba Ghazanfari, Amina Kariminia, Roya Yaraee, Soghrat Faghihzadeh, Sussan K Ardestani, Massoumeh Ebtekar, Ali Mostafaie, Abbas Foroutan, Abbas Rezaei, Jalaleddin Shams, Mahmoud Mahmoudi, Mohammad R Vaez-Mahdavi, Mohammad R Soroush, Mohammadreza Jalali-Nadoushan, Sakine Moaiedmohseni, Soheila Ajdary, Hiedeh Darabi, Mohammad M Naghizadeh, Hadi Kazemi, Zuhair M Hassan
发表日期
2013/11/1
期刊
International immunopharmacology
卷号
17
期号
3
页码范围
931-935
出版商
Elsevier
简介
The most important long-term morbidity problem of sulfur mustard (SM) toxicity is pulmonary complications but the pathogenesis of these complications is not clearly understood. This study evaluates the peripheral blood mononuclear sub-sets and their correlation with pulmonary function in SM exposed civilian cases 20 years post-exposure as gathered in the context of the Sardasht-Iran Cohort Study (SICS). Samples were randomly selected from two groups, SM-exposed (n = 372) and control (n = 128), with the same ethnicity, culture, and demography. Three color flow cytometry was applied for peripheral blood mononuclear sub-population determination. Results indicated a significant decrease in CD45 +/CD3 +, CD45 +/CD3 +/CD4 +, and an increase in CD3 +/CD16+56 + percentages. It was also found that absolute count of NK cells was highly increased in peripheral blood of exposed cases. There was a …
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T Ghazanfari, A Kariminia, R Yaraee, S Faghihzadeh… - International immunopharmacology, 2013