作者
Pere Domingo, Isabel Mur, Gracia María Mateo, Maria del Mar Gutierrez, Virginia Pomar, Natividad de Benito, Noemí Corbacho, Silvia Herrera, Lucia Millan, Jessica Muñoz, Jorge Malouf, Maria Ema Molas, Victor Asensi, Juan Pablo Horcajada, Vicente Estrada, Felix Gutierrez, Ferran Torres, Jose A Perez-Molina, Jesús Fortun, Luisa M Villar, Ulla Hohenthal, Harri Marttila, Tytti Vuorinen, Marika Nordberg, Mika Valtonen, Matthew J Frigault, Michael K Mansour, Naomi J Patel, Ana Fernandes, Liam Harvey, Andrea S Foulkes, Brian C Healy, Ruta Shah, Ana Maria Bensaci, Ann E Woolley, Sarah Nikiforow, Nina Lin, Manish Sagar, Harry Shrager, David S Huckins, Matthew Axelrod, Michael D Pincus, Jorge Fleisher, Jon Lampa, Piotr Nowak, Jan C Vesterbacka, Johan Rasmuson, Paul Skorup, Helena Janols, Katarina F Niward, Katerina Chatzidionysiou, Hilmir Asgeirsson, Åsa Parke, Ola Blennow, Anna-Karin Svensson, Soo Aleman, Anders Sönnerborg, Jan-Inge Henter, Anna Carin Horne, Farah Al-Beidh, Derek Angus, Djillali Annane, Yaseen Arabi, Abigail Beane, Scott Berry, Zahra Bhimani, Marc Bonten, Charlotte Bradbury, Frank Brunkhorst, Meredith Buxton, Allen Cheng, Matt Cove, Menno De Jong, Lennie Derde, Lise Estcourt, Herman Goossens, Anthony Gordon, Cameron Green, Rashan Haniffa, Nao Ichihara, Francois Lamontagne, Patrick Lawler, Ed Litton, John Marshall, Colin McArthur, Daniel McAuley, Shay McGuinness, Bryan McVerry, Stephanie Montgommery, Paul Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Jane Parker, Felipe Reyes, Kathryn Rowan, Hiroki Saito, Marlene Santos, Chris Seymour, Manu Shankar-Hari, Alexis Turgeon, Anne Turner, Wilma van Bentum-Puijk, Frank van de Veerdonk, Steve Webb, Ryan Zarychanski, J Kenneth Baillie, Richard Beasley, Nichola Cooper, Robert Fowler, James Galea, Thomas Hills, Andrew King, Susan Morpeth, Mihai Netea, Kayode Ogungbenro, Ville Pettila, Steve Tong, Tim Uyeki, Taryn Youngstein, Alisa Higgins, Elizabeth Lorenzi, Lindsay Berry, Carlos Salama, Ivan O Rosas, Belén Ruiz-Antorán, Elena Muñez Rubio, Antonio Ramos Martínez, José Campos Esteban, Cristina Avendaño Solá, Reuven Pizov, Jesus Sanz Sanz, Francisco Abad-Santos, Azucena Bautista-Hernández, Lucio García-Fraile, Ana Barrios, Ángela Gutiérrez Liarte, Tamara Alonso Pérez, Sebastian C Rodríguez-García, Gina Mejía-Abril, Jose Carlos Prieto, Rafael Leon, VIVIANE C VEIGA, Phillip Scheinberg, Danielle LC Farias, JOÃO G PRATS, ALEXANDRE B CAVALCANTI, FLAVIA R MACHADO, REGIS G ROSA, Otávio Berwanger
发表日期
2021/8/10
期刊
Jama
卷号
326
期号
6
页码范围
499-518
出版商
American Medical Association
简介
Importance
Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.
Objective
To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.
Data Sources
Trials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts.
Study Selection
Eligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria.
Data …
学术搜索中的文章
P Domingo, I Mur, GM Mateo, M del Mar Gutierrez… - Jama, 2021