查看文章

Objective: To explore the potential of speech data as a digital measure in assessing the progression of Huntington disease (HD) and its clinical implications. Background: Speech changes are an early symptom of Huntington disease (HD) and may occur prior to other motor and cognitive symptoms. Traditional HD assessments utilize clinician-rated outcome measures. These can be limited by observer variability and episodic administration. Digital assessment of speech can provide a quantitative evaluation apt for frequent and remote administration. Design/Methods: Recordings of 33 participants (15 HD, 7 prodromal HD, and 11 control) were collected while reading a passage speech task. Biodigit Speech was used to analyze the recording and extract speech features such as pausing, pitch, and intelligibility. The features were compared between HD, prodromal HD and controls, and also correlated with the Unified …