作者
Franck Mauvais-Jarvis, Heiner K Berthold, Ilaria Campesi, Juan-Jesus Carrero, Santosh Dhakal, Flavia Franconi, Ioanna Gouni-Berthold, Mark L Heiman, Alexandra Kautzky-Willer, Sabra L Klein, Anne Murphy, Vera Regitz-Zagrosek, Karen Reue, Joshua B Rubin
发表日期
2021/4/1
来源
Pharmacological reviews
卷号
73
期号
2
页码范围
730-762
出版商
American Society for Pharmacology and Experimental Therapeutics
简介
In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences of biologic sex produces different in vivo environments for male and female cells. We dissect how these influences of sex modify the pharmacokinetics and pharmacodynamics of multiple drugs and provide examples for common drugs acting on specific organ systems. We also discuss how gender of physicians and patients may influence the therapeutic response to drugs. We aim to highlight sex as a genetic modifier of the pharmacological response to drugs, which should be considered as a necessary step toward precision medicine that will benefit men and women.
Significance Statement
This study discusses the influences of biologic sex on the pharmacokinetics and pharmacodynamics of drugs and provides examples for common drugs acting on specific organ systems. This study also discusses how gender of …
学术搜索中的文章
F Mauvais-Jarvis, HK Berthold, I Campesi, JJ Carrero… - Pharmacological reviews, 2021