作者
L Colombo, M Pagliazzi, S Konugolu Venkata Sekar, D Contini, T Durduran, A Pifferi
发表日期
2020/6/17
期刊
Optics Letters
卷号
45
期号
13
页码范围
3377-3380
出版商
Optical Society of America
简介
Time-domain diffuse correlation spectroscopy (TD-DCS) is a newly emerging optical technique that exploits pulsed, yet coherent light to non-invasively resolve the blood flow in depth. In this work, we have explored TD-DCS at longer wavelengths compared to those previously used in literature (i.e., 750–850 nm). The measurements were performed using a custom-made titanium-sapphire mode-locked laser, operating at 1000 nm, and an InGaAs photomultiplier as a detector. Tissue-mimicking phantoms and in vivo measurements during arterial arm cuff occlusion in adult volunteers were performed to demonstrate the proof of concept. We obtained a good signal-to-noise ratio, following the hemodynamics continuously with a relatively fast (1 Hz) sampling rate. In all the experiments, the auto-correlation functions show a decay rate approximately five-fold slower compared to shorter wavelengths. This work …
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L Colombo, M Pagliazzi, S Konugolu Venkata Sekar… - Optics Letters, 2020