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We review treatment studies for comorbid substance use disorder (SUD) and posttraumatic stress disorder (PTSD). Results show positive outcomes on multiple domains. Most models had more effect on PTSD than SUD, suggesting SUD is harder to treat. Seeking Safety (SS) is the most studied model. It shows positive outcomes, and is the only treatment outperforming a control on both PTSD and SUD. Partial‐dose SS had more mixed results than the full dose. This first‐generation of PTSD/SUD research addresses complex samples excluded from “gold standard” PTSD‐alone literature. Treatments for PTSD/SUD are generally longer than PTSD‐alone treatments and present‐focused, emphasizing stabilization and coping. The few models with past‐focused (exposure‐based) components also incorporated present‐focused approaches for these vulnerable clients. We discuss public health perspectives to advance …