作者
Rory O'Hanlon, Agata Grasso, Michael Roughton, James C Moon, Susan Clark, Ricardo Wage, Jessica Webb, Meghana Kulkarni, Dana Dawson, Leena Sulaibeekh, Badri Chandrasekaran, Chiara Bucciarelli-Ducci, Ferdinando Pasquale, Martin R Cowie, William J McKenna, Mary N Sheppard, Perry M Elliott, Dudley J Pennell, Sanjay K Prasad
发表日期
2010/9/7
期刊
Journal of the American College of Cardiology
卷号
56
期号
11
页码范围
867-874
出版商
American College of Cardiology Foundation
简介
Objectives
We investigated the significance of fibrosis detected by late gadolinium enhancement cardiovascular magnetic resonance for the prediction of major clinical events in hypertrophic cardiomyopathy (HCM).
Background
The role of myocardial fibrosis in the prediction of sudden death and heart failure in HCM is unclear with a lack of prospective data.
Methods
We assessed the presence and amount of myocardial fibrosis in HCM patients and prospectively followed them for the development of morbidity and mortality in patients over 3.1 ± 1.7 years.
Results
Of 217 consecutive HCM patients, 136 (63%) showed fibrosis. Thirty-four of the 136 patients (25%) in the fibrosis group but only 6 of 81 (7.4%) patients without fibrosis reached the combined primary end point of cardiovascular death, unplanned cardiovascular admission, sustained ventricular tachycardia or ventricular fibrillation, or appropriate implantable …
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R O'Hanlon, A Grasso, M Roughton, JC Moon, S Clark… - Journal of the American College of Cardiology, 2010