作者
Mozhdeh Sojoodi, Leslie Stradiot, Karo Tanaka, Yves Heremans, Gunter Leuckx, Vanessa Besson, Willem Staels, Mark Van de Casteele, Giovanna Marazzi, David Sassoon, Harry Heimberg, Paola Bonfanti
发表日期
2016/7
期刊
Diabetologia
卷号
59
期号
7
页码范围
1474-1479
出版商
Springer Berlin Heidelberg
简介
Aims/hypothesis
Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult. The aim of the present study was to define Pw1 expression in the embryonic and adult pancreas and investigate its role in the beta cell cycle in Pw1 wild-type and mutant mice.
Methods
We analysed PW1 expression by immunohistochemistry in pancreas of nonpregant and pregnant mice and following injury by partial duct ligation. Its role in the beta cell cycle was studied in vivo using a novel conditional knockout mouse and in vitro by lentivirus-mediated gene knockdown.
Results
We showed that PW1 is expressed in early pancreatic progenitors at E9.5 but becomes …
学术搜索中的文章
M Sojoodi, L Stradiot, K Tanaka, Y Heremans… - Diabetologia, 2016