作者
José Altamirano, Rosa Miquel, Aezam Katoonizadeh, Juan G Abraldes, Andrés Duarte–Rojo, Alexandre Louvet, Salvador Augustin, Rajeshwar P Mookerjee, Javier Michelena, Thomas C Smyrk, David Buob, Emmanuelle Leteurtre, Diego Rincón, Pablo Ruiz, Juan Carlos García–Pagán, Carmen Guerrero–Marquez, Patricia D Jones, A Sidney Barritt IV, Vicente Arroyo, Miquel Bruguera, Rafael Bañares, Pere Ginès, Juan Caballería, Tania Roskams, Frederik Nevens, Rajiv Jalan, Philippe Mathurin, Vijay H Shah, Ramón Bataller
发表日期
2014/5/1
期刊
Gastroenterology
卷号
146
期号
5
页码范围
1231-1239. e6
出版商
WB Saunders
简介
Background & Aims
There is no histologic classification system to determine prognoses of patients with alcoholic hepatitis (AH). We identified histologic features associated with disease severity and created a histologic scoring system to predict short-term (90-day) mortality.
Methods
We analyzed data from 121 patients admitted to the Liver Unit (Hospital Clinic, Barcelona, Spain) from January 2000 to January 2008 with features of AH and developed a histologic scoring system to determine the risk of death using logistic regression. The system was tested and updated in a test set of 96 patients from 5 academic centers in the United States and Europe, and a semiquantitative scoring system called the Alcoholic Hepatitis Histologic Score (AHHS) was developed. The system was validated in an independent set of 109 patients. Interobserver agreement was evaluated by weighted κ statistical analysis.
Results
The degree …
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J Altamirano, R Miquel, A Katoonizadeh, JG Abraldes… - Gastroenterology, 2014