作者
Valerio Nobili, Francesco Vizzutti, Umberto Arena, Juan G Abraldes, Fabio Marra, Andrea Pietrobattista, Rodolfo Fruhwirth, Matilde Marcellini, Massimo Pinzani
发表日期
2008/8
期刊
Hepatology
卷号
48
期号
2
页码范围
442-448
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in chronic liver disease patients. In this study, we assessed the value of TE for the prediction of fibrosis stage in a cohort of pediatric patients with nonalcoholic steatohepatitis. Furthermore, TE interobserver agreement was evaluated. TE was performed in 52 consecutive biopsy‐proven nonalcoholic steatohepatitis patients (32 males, 20 females, age 13.6 ± 2.44 years). The area under the receiver operating characteristic curves for the prediction of “any” (≥1), significant (≥2), or advanced fibrosis (≥3) were 0.977, 0.992, and 1, respectively. Calculation of multilevel likelihood ratios showed that TE values <5, <7, and <9 kPa, suggest the presence of “any” fibrosis, significant fibrosis, and advanced fibrosis, respectively. TE values between 5 and 7 kPa predict a fibrosis stage of 1, but with some degree of …
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