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Background

Breast cancer is the most common and frequent cause of death in women in all types of cancer. Current treatment protocols do not provide a complete cure and targeting therapy can provide an important avenue for successful treatment of breast cancer. In this study, we aim to determine the therapeutic effects of the drug-conjugated carrier system with the conjugation of peptide sequence and antibody on HER2-positive breast cancer cells.

Methods

The selectivity of single nanocarriers were compared with doxorubicin (DOX) loaded-HER2 targeting peptide (LTVSPWY) and DOX loaded-monoclonal antibody (Herceptin®) on HER2-positive and HER2-negative breast cells. After defining the physicochemical characterization of micelle-based nanocarriers, the cytotoxic effects of micelles on healthy breast epithelial cells (MCF-10A, HER2-negative) and breast cancer cells (SKBR3-HER2-positive) were …