作者
Ellen M Mowry, Emmanuelle Waubant, Charles E McCulloch, Darin T Okuda, Alan A Evangelista, Robin R Lincoln, Pierre‐Antoine Gourraud, Don Brenneman, Mary C Owen, Pamela Qualley, Monica Bucci, Stephen L Hauser, Daniel Pelletier
发表日期
2012/8
期刊
Annals of neurology
卷号
72
期号
2
页码范围
234-240
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
We sought to determine whether vitamin D status is associated with developing new T2 lesions or contrast‐enhancing lesions on brain magnetic resonance imaging (MRI) in relapsing multiple sclerosis (MS).
Methods
EPIC is a 5‐year longitudinal MS cohort study at the University of California at San Francisco. Participants had clinical evaluations, brain MRI, and blood draws annually. From the overall cohort, we evaluated patients with clinically isolated syndrome or relapsing–remitting MS at baseline. In univariate and multivariate (adjusted for age, sex, ethnicity, smoking, and MS treatments) repeated measures analyses, annual 25‐hydroxyvitamin D levels were evaluated for their association with subsequent new T2‐weighted and gadolinium‐enhancing T1‐weighted lesions on brain MRI, clinical relapses, and disability (Expanded Disability Status Scale [EDSS]).
Results
A total of 2,362 3T brain MRI …
学术搜索中的文章
EM Mowry, E Waubant, CE McCulloch, DT Okuda… - Annals of neurology, 2012