作者
Richard G Hunter, Gen Murakami, Scott Dewell, Ma’ayan Seligsohn, Miriam ER Baker, Nicole A Datson, Bruce S McEwen, Donald W Pfaff
发表日期
2012/10/23
期刊
Proceedings of the National Academy of Sciences
卷号
109
期号
43
页码范围
17657-17662
出版商
National Academy of Sciences
简介
The hippocampus is a highly plastic brain region particularly susceptible to the effects of environmental stress; it also shows dynamic changes in epigenetic marks in response to stress and learning. We have previously shown that, in the rat, acute (30 min) restraint stress induces a substantial, regionally specific, increase in hippocampal levels of the repressive histone H3 lysine 9 trimethylation (H3K9me3). Because of the large magnitude of this effect and the fact that stress can induce the expression of endogenous retroviruses and transposable elements in many systems, we hypothesized that the H3K9me3 response was targeted to these elements as a means of containing potential genomic instability. We used ChIP coupled with next generation sequencing (ChIP-Seq) to determine the genomic localization of the H3K9me3 response. Although there was a general increase in this response across the genome …
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RG Hunter, G Murakami, S Dewell, M Seligsohn… - Proceedings of the National Academy of Sciences, 2012