作者
Rosa Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brône, Guy C Brown, Oleg Butovsky, Monica J Carson, Bernardo Castellano, Marco Colonna, Sally A Cowley, Colm Cunningham, Dimitrios Davalos, Philip L De Jager, Bart De Strooper, Ádám Dénes, Bart JL Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K Glass, Ozgun Gokce, Diego Gomez-Nicola, Berta González, Siamon Gordon, Manuel B Graeber, Andrew D Greenhalgh, Pierre Gressens, Melanie Greter, David H Gutmann, Christian Haass, Michael T Heneka, Frank Heppner, Soyon Hong, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Michela Matteoli, Barry McColl, Veronique E Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V Hugh Perry, Phillip G Popovich, Josef Priller, Davide Ragozzino, Richard M Ransohoff, Michael W Salter, Anne Schaefer, Dorothy P Schafer, Michal Schwartz, Mikael Simons, Wolfgang J Streit, Tuan Leng Tay, Li-Huei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valerie Wittamer, Susanne A Wolf, Long-Jun Wu, Tony Wyss-Coray
发表日期
2022/3/22
简介
Microglial research has been constrained by a rolling series of dichotomies such as “resting versus activated” or “M1 versus M2”. This Manichean perspective of good or bad microglia is in sharp contrast with the wide repertoire of microglial functions, exerted from development to aging and diseases, brought to light in recent years. New designations continuously arising in the attempt to describe different microglial states from transcriptomics or other readouts may thus easily lead to the misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts in microglial research and discussed our current understanding of microglial states as a dynamic concept. In this white paper, we provide a series of recommendations on the use of microglial nomenclature for researchers, reviewers and editors, including neophytes. We discuss gaps in knowledge and future challenges to tackle, providing a conceptual framework to understand microglial states.
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R Paolicelli, A Sierra, B Stevens, ME Tremblay… - 2022