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The present study examines the contribution of psychotherapist variables to change in depressive symptoms in a large clinical trial comparing the efficacy of the cognitive–behavioral analysis system of psychotherapy, the antidepressant nefazodone, and the combination of both in the treatment of chronic depression. Greater change on the Hamilton Rating Scale for Depression (HRSD) was associated with greater emphasis on the therapeutic relationship, lower overall psychotherapy caseload, therapist psychodynamic orientation, and supervisory status. There was no relationship between HRSD change and therapist sex, age, or years of experience.