作者
Martin B Keller, James P McCullough, Daniel N Klein, Bruce Arnow, David L Dunner, Alan J Gelenberg, John C Markowitz, Charles B Nemeroff, James M Russell, Michael E Thase, Madhukar H Trivedi, Janice A Blalock, Frances E Borian, Darlene N Jody, Charles DeBattista, Lorrin M Koran, Alan F Schatzberg, Jan Fawcett, Robert MA Hirschfeld, Gabor Keitner, Ivan Miller, James H Kocsis, Susan G Kornstein, Rachel Manber, Philip T Ninan, Barbara Rothbaum, A John Rush, Dina Vivian, John Zajecka
发表日期
2000/5/18
期刊
New England journal of medicine
卷号
342
期号
20
页码范围
1462-1470
出版商
Massachusetts Medical Society
简介
Background
Patients with chronic forms of major depression are difficult to treat, and the relative efficacy of medications and psychotherapy is uncertain.
Methods
We randomly assigned 681 adults with a chronic nonpsychotic major depressive disorder to 12 weeks of outpatient treatment with nefazodone (maximal dose, 600 mg per day), the cognitive behavioral-analysis system of psychotherapy (16 to 20 sessions), or both. At base line, all patients had scores of at least 20 on the 24-item Hamilton Rating Scale for Depression (indicating clinically significant depression). Remission was defined as a score of 8 or less at weeks 10 and 12. For patients who did not have remission, a satisfactory response was defined as a reduction in the score by at least 50 percent from base line and a score of 15 or less. Raters were unaware of the patients' treatment assignments.
Results
Of the 681 patients, 662 attended at least …
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MB Keller, JP McCullough, DN Klein, B Arnow… - New England journal of medicine, 2000