作者
Kristine Yaffe, Alison M Laffan, Stephanie Litwack Harrison, Susan Redline, Adam P Spira, Kristine E Ensrud, Sonia Ancoli-Israel, Katie L Stone
发表日期
2011/8/10
期刊
Jama
卷号
306
期号
6
页码范围
613-619
出版商
American Medical Association
简介
Context
Sleep-disordered breathing (characterized by recurrent arousals from sleep and intermittent hypoxemia) is common among older adults. Cross-sectional studies have linked sleep-disordered breathing to poor cognition; however, it remains unclear whether sleep-disordered breathing precedes cognitive impairment in older adults.
Objectives
To determine the prospective relationship between sleep-disordered breathing and cognitive impairment and to investigate potential mechanisms of this association.
Design, Setting, and Participants
Prospective sleep and cognition study of 298 women without dementia (mean [SD] age: 82.3 [3.2] years) who had overnight polysomnography measured between January 2002 and April 2004 in a substudy of the Study of Osteoporotic Fractures. Sleep-disordered breathing was defined as an apnea-hypopnea index of 15 or more events per hour of sleep. Multivariate logistic …
引用总数
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