作者
Xiaodong Zhang, Jean-Martin Beaulieu, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caron
发表日期
2004/7/9
期刊
Science
卷号
305
期号
5681
页码范围
217-217
出版商
American Association for the Advancement of Science
简介
Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the substitution of Pro447 with Arg447 and leads to decreased serotonin levels in PC12 cells. Moreover, in BALB/cJ and DBA/2 mice that are homozygous for the 1473G allele, brain serotonin tissue content and synthesis are reduced in comparison to C57Bl/6 and 129X1/SvJ mice that are homozygous for the 1473C allele. Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis.
引用总数
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