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We investigated the association between county-level trends in opioid prescribing rates, a proxy for opioid misuse, and rates of reported gonorrhea (GC) among males in the United States.

We used linear mixed-model regression analyses to evaluate the association between county-level trends in opioid prescribing rates and rates of reported GC among males during 2010–2015.

There was a positive association between trends in county-level opioid prescribing rates and rates of GC among males (β = 0.068, 95% confidence interval [CI] = 0.030, 0.105) during 2010–2015. However, the magnitude of this association decreased significantly over time in counties where opioid prescribing rates decreased (β = −0.018, 95% CI = −0.030, −0.006) and remained stable (β = −0.020, 95% CI = −0.038, −0.002) but was unchanged in counties where opioid prescribing rates increased (β = −0.029, 95% CI …