作者
Tom van der Poll, Manu Shankar-Hari, W Joost Wiersinga
发表日期
2021/11/9
来源
Immunity
卷号
54
期号
11
页码范围
2450-2464
出版商
Elsevier
简介
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. This recently implemented definition does not capture the heterogeneity or the underlying pathophysiology of the syndrome, which is characterized by concurrent unbalanced hyperinflammation and immune suppression. Here, we review current knowledge of aberrant immune responses during sepsis and recent initiatives to stratify patients with sepsis into subgroups that are more alike from a clinical and/or pathobiological perspective, which could be key for identification of patients who are more likely to benefit from specific immune interventions.
学术搜索中的文章
T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021