作者
Sailendra Singh, Jonnala Kotesh Kumar, Dharmendra Saikia, Karuna Shanker, Jay Prakash Thakur, Arvind Singh Negi, Suchitra Banerjee
发表日期
2010/9/1
期刊
European journal of medicinal chemistry
卷号
45
期号
9
页码范围
4379-4382
出版商
Elsevier Masson
简介
A labdane diterpene dialdehyde was first time isolated from the chloroform extract of rhizomes of Curcuma amada. This compound exhibited antitubercular activity (MIC=500μg/mL) against Mycobacterium tuberculosis H37Rv strain in BACTEC-460 assay. Two of its semisynthetic analogues also exhibited antitubercular activity at 250–500μg/mL. It is the first report on isolation and antimycobacterial activity of this dialdehyde from C. amada.
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S Singh, JK Kumar, D Saikia, K Shanker, JP Thakur… - European journal of medicinal chemistry, 2010