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A novel multi-targeting nanocarrier (SiPc-polymer) for photodynamic therapy (PDT) has been successfully polymerized via the incorporation of silicon(IV) phthalocyanine dichloride (SiPcCl2) to the thermoresponsive PEG-methacrylates based polymers. The resulting SiPc-polymer was characterized by 1H NMR spectroscopy, GPC, UV-Vis and elemental analysis. The lower critical solution temperature (LCST) of the SiPc-polymer can be easily controlled via changing the ratio of the applied monomers, di(ethylene glycol) methyl ether methacrylate (DEGMEMA), oligo(ethylene glycol) methyl ether methacrylate (OEGMEMA, Mw = 475 g mol−1) and 2-hydroxyethyl methacrylate (HEMA). The synthesized polymers assemble into nanoparticles (70 nm) in aqueous solution, which normally exhibits permeation and retention (EPR) effects, the thermo-responsive features provide the possibility to selectively accumulate at a …