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The present study aims to investigate the different patterns of heavy metal bio-mineralization by some molluscs species (bivalves and gastropods) collected from the Timsah and Great Bitter lakes within their shells. Samples were collected from the two lakes, during the period from May 2016 to June 2017. The samples included seven mollusc species. The bio-available forms of the selected heavy metals: iron (Fe), manganese (Mn), Nickel (Ni), lead (Pb), cadmium (Cd), copper (Cu), and zinc (Zn), were determined in triplicates, using flame Atomic Absorption Spectrophotometer, then three individuals of each gastropod and bivalve species were selected for measuring heavy metals concentrations in their shells. Results showed that, the harvested (Fe) and (Mn) were the highest mineralized metals in the shell structures of the different species; while their bio-mineralization factor of metals (BMF_M) ratios were …