作者
Nina G Steele, Giulia Biffi, Samantha B Kemp, Yaqing Zhang, Donovan Drouillard, LiJyun Syu, Yuan Hao, Tobiloba E Oni, Erin Brosnan, Ela Elyada, Abhishek Doshi, Christa Hansma, Carlos Espinoza, Ahmed Abbas, Stephanie The, Valerie Irizarry-Negron, Christopher J Halbrook, Nicole E Franks, Megan T Hoffman, Kristee Brown, Eileen S Carpenter, Zeribe C Nwosu, Craig Johnson, Fatima Lima, Michelle A Anderson, Youngkyu Park, Howard C Crawford, Costas A Lyssiotis, Timothy L Frankel, Arvind Rao, Filip Bednar, Andrzej A Dlugosz, Jonathan B Preall, David A Tuveson, Benjamin L Allen, Marina Pasca di Magliano
发表日期
2021/4/1
期刊
Clinical Cancer Research
卷号
27
期号
7
页码范围
2023-2037
出版商
American Association for Cancer Research
简介
Purpose
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by an extensive fibroinflammatory stroma, which includes abundant cancer-associated fibroblast (CAF) populations. PDAC CAFs are heterogeneous, but the nature of this heterogeneity is incompletely understood. The Hedgehog pathway functions in PDAC in a paracrine manner, with ligands secreted by cancer cells signaling to stromal cells in the microenvironment. Previous reports investigating the role of Hedgehog signaling in PDAC have been contradictory, with Hedgehog signaling alternately proposed to promote or restrict tumor growth. In light of the newly discovered CAF heterogeneity, we investigated how Hedgehog pathway inhibition reprograms the PDAC microenvironment.
Experimental Design
We used a combination of pharmacologic inhibition, gain- and loss-of-function …
学术搜索中的文章
NG Steele, G Biffi, SB Kemp, Y Zhang, D Drouillard… - Clinical Cancer Research, 2021