作者
Emily K Sims, Susan Geyer, Suzanne Bennett Johnson, Ingrid Libman, Laura M Jacobsen, David Boulware, Lisa E Rafkin, Della Matheson, Mark A Atkinson, Henry Rodriguez, Maria Spall, Helena Elding Larsson, Diane K Wherrett, Carla J Greenbaum, Jeffrey Krischer, Linda A DiMeglio, Type 1 Diabetes TrialNet Study Group
发表日期
2019/12/1
期刊
Diabetes Care
卷号
42
期号
12
页码范围
2228-2236
出版商
American Diabetes Association
简介
OBJECTIVE
To better understand potential facilitators of individual engagement in type 1 diabetes natural history and prevention studies through analysis of enrollment data in the TrialNet Pathway to Prevention (PTP) study.
RESEARCH DESIGN AND METHODS
We used multivariable logistic regression models to examine continued engagement of eligible participants at two time points: 1) the return visit after screening to confirm an initial autoantibody-positive (Ab+) test result and 2) the initial oral glucose tolerance test (OGTT) for enrollment into the monitoring protocol.
RESULTS
Of 5,387 subjects who screened positive for a single autoantibody (Ab), 4,204 (78%) returned for confirmatory Ab testing. Younger age was associated with increased odds of returning for Ab confirmation (age <12 years vs. >18 years: odds ratio [OR] 2.12, P < 0.0001). Racial and …
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