作者
Bashkim Kadriu, Maximillian Greenwald, Ioline D Henter, Jessica R Gilbert, Christoph Kraus, Lawrence T Park, Carlos A Zarate Jr
发表日期
2021/1/1
来源
International Journal of Neuropsychopharmacology
卷号
24
期号
1
页码范围
8-21
出版商
Oxford University Press
简介
Background
The glutamatergic modulator ketamine has created a blueprint for studying novel pharmaceuticals in the field. Recent studies suggest that “classic” serotonergic psychedelics (SPs) may also have antidepressant efficacy. Both ketamine and SPs appear to produce rapid, sustained antidepressant effects after a transient psychoactive period.
Methods
This review summarizes areas of overlap between SP and ketamine research and considers the possibility of a common, downstream mechanism of action. The therapeutic relevance of the psychoactive state, overlapping cellular and molecular effects, and overlapping electrophysiological and neuroimaging observations are all reviewed.
Results
Taken together, the evidence suggests a potentially shared mechanism wherein both ketamine and SPs may engender rapid neuroplastic effects in a …
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B Kadriu, M Greenwald, ID Henter, JR Gilbert, C Kraus… - International Journal of Neuropsychopharmacology, 2021