作者
Alicia Santos, Eugenia Resmini, Iris Crespo, Patricia Pires, Yolanda Vives-Gilabert, Esther Granell, Elena Valassi, Beatriz Gomez-Anson, M Antonia Martínez-Momblán, Maria Mataro, Susan M Webb
发表日期
2014/10
期刊
European Journal of Endocrinology
卷号
171
期号
4
页码范围
461-469
出版商
Oxford University Press
简介
Objective
Cushing's syndrome (CS) is associated with neuropsychological deficits. As the cerebellum plays a key role in neuropsychological functions it may be affected in CS. The aim of this study was to investigate whether patients with CS have a smaller cerebellar volume than healthy controls, and to analyse whether cerebellar volume is associated with neuropsychological performance and clinical parameters.
Design
A cross-sectional study was performed.
Methods
Thirty-six CS patients (15 with active CS and 21 with CS in remission) and 36 controls matched for age, sex, and education underwent neuropsychological testing, quality of life assessment, clinical evaluation, and magnetic resonance imaging brain scan. Cerebellar volumes (white matter and cortex, bilateral) were calculated using FreeSurfer Software.
Results
Patients …
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A Santos, E Resmini, I Crespo, P Pires… - European Journal of Endocrinology, 2014