作者
Cornelie D Andela, Femke M van Haalen, Oskar Ragnarsson, Eleni Papakokkinou, Gudmundur Johannsson, Alicia Santos, Susan M Webb, Nienke R Biermasz, Nic JA van der Wee, Alberto M Pereira
发表日期
2015/7
来源
European Journal of Endocrinology
卷号
173
期号
1
页码范围
R1-R14
出版商
Oxford University Press
简介
Background
Cushing's syndrome (CS) is characterized by excessive exposure to cortisol, and is associated with both metabolic and behavioral abnormalities. Symptoms improve substantially after biochemical cure, but may persist during long-term remission. The causes for persistent morbidity are probably multi-factorial, including a profound effect of cortisol excess on the brain, a major target area for glucocorticoids.
Objective
To review publications evaluating brain characteristics in patients with CS using magnetic resonance imaging (MRI).
Methods
Systematic review of literature published in PubMed, Embase, Web of Knowledge, and Cochrane databases.
Results
Nineteen studies using MRI in patients with CS were selected, including studies in patients with active disease, patients in long-term remission, and longitudinal studies …
学术搜索中的文章
CD Andela, FM van Haalen, O Ragnarsson… - European Journal of Endocrinology, 2015