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To correct for RF inhomogeneity for in vivo ¹²⁹Xe ventilation MRI using flip‐angle mapping enabled by randomized 3D radial acquisitions. To extend this RF‐depolarization mapping approach to create a flip‐angle map template applicable to arbitrary acquisition strategies, and to compare these approaches to conventional bias field correction.

RF‐depolarization mapping was evaluated first in digital simulations and then in 51 subjects who had undergone radial ¹²⁹Xe ventilation MRI in the supine position at 3T (views = 3600; samples/view = 128; TR/TE = 4.5/0.45 ms; flip angle = 1.5; FOV = 40 cm). The images were corrected using newly developed RF‐depolarization and templated‐based methods and the resulting quantitative ventilation metrics (mean, coefficient of variation, and gradient) were compared to those resulting from N4ITK correction.

RF‐depolarization and template …