查看文章

In the rat brain, a heteromeric association between adenosine A₁ and purinergic P2Y₁ receptors has been demonstrated. It is suggested that this association plays an important role in the control of purine‐mediated responses during pathophysiological conditions. Recently, we have demonstrated that these receptors colocalize on glutamatergic synaptic and astroglial membranes in rat hippocampus and reciprocally interact, thus modulating their functional responses at the G protein coupling level. In the present work, by means of immunoprecipitation studies, we demonstrated that A₁ and P2Y₁ receptors are present in human astroglial cells (ADF) and aggregate to form a multimeric complex. P2Y₁ receptor activation by its agonist, 2‐methylthio‐adenosine 5′‐diphosphate (MeSADP), induced a time‐dependent reduction in agonist‐mediated A₁ receptor functional responses, causing a drop in A₁ receptor …