作者
Ilaria Tonazzini, MARIA LETIZIA Trincavelli, M Montali, Claudia Martini
发表日期
2008/10
期刊
Journal of neuroscience research
卷号
86
期号
13
页码范围
2857-2866
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
In the rat brain, a heteromeric association between adenosine A1 and purinergic P2Y1 receptors has been demonstrated. It is suggested that this association plays an important role in the control of purine‐mediated responses during pathophysiological conditions. Recently, we have demonstrated that these receptors colocalize on glutamatergic synaptic and astroglial membranes in rat hippocampus and reciprocally interact, thus modulating their functional responses at the G protein coupling level. In the present work, by means of immunoprecipitation studies, we demonstrated that A1 and P2Y1 receptors are present in human astroglial cells (ADF) and aggregate to form a multimeric complex. P2Y1 receptor activation by its agonist, 2‐methylthio‐adenosine 5′‐diphosphate (MeSADP), induced a time‐dependent reduction in agonist‐mediated A1 receptor functional responses, causing a drop in A1 receptor …
学术搜索中的文章
I Tonazzini, ML Trincavelli, M Montali, C Martini - Journal of neuroscience research, 2008