作者
Xuelai Liu, Pui‐yan Lee, Chi‐ming Ho, Vincent CH Lui, Yan Chen, Chi‐ming Che, Paul KH Tam, Kenneth KY Wong
发表日期
2010/3/1
期刊
ChemMedChem
卷号
5
期号
3
页码范围
468-475
出版商
WILEY‐VCH Verlag
简介
With advances in nanotechnology, pure silver has been recently engineered into nanometer‐sized particles (diameter <100 nm) for use in the treatment of wounds. In conjunction with other studies, we previously demonstrated that the topical application of silver nanoparticles (AgNPs) can promote wound healing through the modulation of cytokines. Nonetheless, the question as to whether AgNPs can affect various skin cell types—keratinocytes and fibroblasts—during the wound‐healing process still remains. Therefore, the aim of this study was to focus on the cellular response and events of dermal contraction and epidermal re‐epithelialization during wound healing under the influence of AgNPs; for this we used a full‐thickness excisional wound model in mice. The wounds were treated with either AgNPs or control with silver sulfadiazine, and the proliferation and biological events of keratinocytes and fibroblasts …
引用总数
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X Liu, P Lee, C Ho, VCH Lui, Y Chen, C Che, PKH Tam… - ChemMedChem, 2010