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Premenopausal women have blood pressure that is ~10mmHg lower than age-matched men. Women incur cardiovascular disease risk at lower blood pressures than men, implying that this sex difference in blood pressure is functionally important; however, clinical management of blood pressure is identical in men and women (Ji et al Circulation 2021). Recently, a study from our lab examined an olfactory receptor (OLFR558) that is expressed in renal juxtaglomerular cells, as well as in all renal blood vessels and a subset of extrarenal blood vessels. We find that OLFR558 is required for sex differences in blood pressure, as sex differences in blood pressure are entirely absent in Olfr558 knockout mice (Xu et al BioRxiv 2022). However, there is a gap in our knowledge regarding how OLFR558 influences blood pressure, and, in the mechanism underlying the blood pressure differences between the sexes. We …