作者
Maurizio Callari, Valeria Musella, Eleonora Di Buduo, Marialuisa Sensi, Patrizia Miodini, Matteo Dugo, Rosaria Orlandi, Roberto Agresti, Biagio Paolini, Maria Luisa Carcangiu, Vera Cappelletti, Maria Grazia Daidone
发表日期
2014/10/1
期刊
Molecular oncology
卷号
8
期号
7
页码范围
1278-1289
出版商
No longer published by Elsevier
简介
The majority of gene expression signatures developed to predict the likelihood to relapse in breast cancer (BC) patients assigns a high risk score to patients with Estrogen Receptor (ER) negative or highly proliferating tumors. We aimed to identify a signature of differentially expressed (DE) metagenes, rather than single DE genes, associated with distant metastases beyond classical risk factors.
We used 105 gene expression profiles from consecutive BCs to identify metagenes whose prognostic role was defined on an independent series of 92 ESR1+/ERBB2− node-negative BCs (42 cases developing metastases within 5 years from diagnosis and 50 cases metastasis-free for more than 5 years, comparable for age, tumor size, ER status and surgery). Findings were validated on publicly available datasets of 684 node-negative BCs including all the subtypes.
Only a metagene containing interferon-induced genes (IFN …
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M Callari, V Musella, E Di Buduo, M Sensi, P Miodini… - Molecular oncology, 2014