作者
Melissa E Munroe, Rufei Lu, Yan D Zhao, Dustin A Fife, Julie M Robertson, Joel M Guthridge, Timothy B Niewold, George C Tsokos, Michael P Keith, John B Harley, Judith A James
发表日期
2016/11/1
期刊
Annals of the rheumatic diseases
卷号
75
期号
11
页码范围
2014-2021
出版商
BMJ Publishing Group Ltd
简介
Objectives
The relationship of immune dysregulation and autoantibody production that may contribute to systemic lupus erythematosus (SLE) pathogenesis is unknown. This study evaluates the individual and combined contributions of autoantibodies, type I interferon (IFN-α) activity, and IFN-associated soluble mediators to disease development leading to SLE.
Methods
Serial serum specimens from 55 individuals collected prior to SLE classification (average timespan=4.3 years) and unaffected healthy controls matched by age (±5 years), gender, race and time of sample procurement were obtained from the Department of Defense Serum Repository. Levels of serum IFN-α activity, IFN-associated mediators and autoantibodies were evaluated and temporal relationships assessed by growth curve modelling, path analysis, analysis of covariance and random forest models.
Results
In cases, but not matched controls …
学术搜索中的文章
ME Munroe, R Lu, YD Zhao, DA Fife, JM Robertson… - Annals of the rheumatic diseases, 2016