作者
Mark Sinyor, Anthony J Levitt, Amy H Cheung, Ayal Schaffer, Alex Kiss, Yekta Dowlati, Krista L Lanctôt
发表日期
2010/1/26
来源
The Journal of clinical psychiatry
卷号
71
期号
3
页码范围
4632
出版商
Physicians Postgraduate Press, Inc.
简介
Objective: To determine if the inclusion of a placebo arm and/or the number of active comparators in antidepressant trials influences the response rates of the active medication and/or placebo.
Data Sources: Searches of MEDLINE,
PsycINFO, and pharmaceutical Web sites for published trials or trials conducted but unpublished between January 1996 and October 2007.
Study Selection: 2,275 citations were reviewed, 285 studies were retrieved, and 90 were included in the analysis. Trials reporting response and/or remission rates in adult subjects treated with an antidepressant monotherapy for unipolar major depression were included.
Data Extraction: The primary investigator recorded the number of responders and/or remitters in the intent-to-treat population of each study arm or computed these numbers using the quoted rates.
Data Synthesis: Poisson regression analyses demonstrated that mean response rate for …
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