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Pre-formulation studies are conducted each time new nanoparticulate formulations are in development to the selection of a satisfactory drug delivery system. We hypothesized that laser diffraction technique could be used as an initial screening, being an excellent tool to save time and reduce the number of necessary tests to select formulations. We built radar charts based on laser diffraction data as a new approach to determine the fingerprints of nanocarrier formulations in order to select promising drug delivery systems. To validate our approach different lipophilic dispersions of poly(epsilon-caprolactone) and polysorbate 80, combined with 4 solid materials: sorbitan monostearate (I), cetyl palmitate (II), stearic acid (III) or cholesterol (IV), and 4 oils: capric/caprylic triglycerides (A), mineral oil (B), octyl methoxycinnamate (C) or oleic acid (D), were prepared. Formulations were analyzed by laser diffraction, as well as …