作者
Theodoros Karampitsakos, Paolo Spagnolo, Nesrin Mogulkoc, Wim A Wuyts, Sara Tomassetti, Elisabeth Bendstrup, Maria Molina‐Molina, Effrosyni D Manali, Ömer Selim Unat, Francesco Bonella, Nicolas Kahn, Lykourgos Kolilekas, Elisabetta Rosi, Leonardo Gori, Claudia Ravaglia, Venerino Poletti, Zoe Daniil, Thomas Skovhus Prior, Ilias C Papanikolaou, Samantha Aso, Stavros Tryfon, Despoina Papakosta, Vasillios Tzilas, Elisabetta Balestro, Spyridon Papiris, Katerina Antoniou, Demosthenes Bouros, Athol Wells, Michael Kreuter, Argyris Tzouvelekis
发表日期
2023/1
期刊
Respirology
卷号
28
期号
1
页码范围
56-65
出版商
John Wiley & Sons, Ltd
简介
Background and Objective
There remains a paucity of large databases for patients with idiopathic pulmonary fibrosis (IPF) and lung cancer. We aimed to create a European registry.
Methods
This was a multicentre, retrospective study across seven European countries between 1 January 2010 and 18 May 2021.
Results
We identified 324 patients with lung cancer among 3178 patients with IPF (prevalence = 10.2%). By the end of the 10 year‐period following IPF diagnosis, 26.6% of alive patients with IPF had been diagnosed with lung cancer. Patients with IPF and lung cancer experienced increased risk of all‐cause mortality than IPF patients without lung cancer (HR: 1.51, [95% CI: 1.22–1.86], p < 0.0001). All‐cause mortality was significantly lower for patients with IPF and lung cancer with a monocyte count of either <0.60 or 0.60–<0.95 K/μl than patients with monocyte count ≥0.95 K/μl (HR [<0.60 vs. ≥0.95 …
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T Karampitsakos, P Spagnolo, N Mogulkoc, WA Wuyts… - Respirology, 2023