作者
María S García-Gutiérrez, Antonio Ortega-Álvaro, Arnau Busquets-García, Jose M Pérez-Ortiz, Laura Caltana, María Jimena Ricatti, Alicia Brusco, Rafael Maldonado, Jorge Manzanares
发表日期
2013/10/1
期刊
Neuropharmacology
卷号
73
页码范围
388-396
出版商
Pergamon
简介
In this study, the role of CB2r on aversive memory consolidation was further evaluated. Mice lacking CB2r (CB2KO) and their corresponding littermates (WT) were exposed to the step-down inhibitory avoidance test (SDIA). MAP2, NF200 and synaptophysin (SYN)-immunoreactive fibers were studied in the hippocampus (HIP) of both genotypes. The number of synapses, postsynaptic density thickness and the relation between the synaptic length across the synaptic cleft and the distance between the synaptic ends were evaluated in the HIP (dentate gyrus (DG) and CA1 fields) by electron microscopy. Brain-derived neurotrophic factor (BDNF), glucocorticoid receptor (NR3C1) gene expressions and mTOR/p70S6K signaling cascade were evaluated in the HIP and prefrontal cortex (PFC). Finally, the effects of acute administration of CB2r-agonist JWH133 or CB2r-antagonist AM630 on memory consolidation were …
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MS García-Gutiérrez, A Ortega-Álvaro… - Neuropharmacology, 2013